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ey0018.11-2 | New hope: Increased diagnostic yield for disease causing MC4R variants and pharmacological treatment options | ESPEYB18

11.2. Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signalling

H Israeli , O Degtjarik , F Fierro , V Chunilal , AK Gill , NJ Roth , J Botta , V Prabahar , Y Peleg , LF Chan , D Ben-Zvi , PJ McCormick , Y Niv , M Shalev-Benami

Science 2021;372(6544): 808–814 doi: https://doi.org/10.1126/science.abf7958Isreali et al. describe the molecular structure of the melanocortin 4 receptor (MC4R) complexed with its effector G protein (Gs alpha) and setmelanotide, a pharmacological agonist of MC4R.MC4R is a known key element in body weight regulation, connecting response to leptin with inhibition o...

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ey0015.9-8 | Growth, growth hormone and puberty in chronic diseases: novel insights from clinical practice | ESPEYB15

9.8 Growth and weight gain in children with juvenile idiopathic arthritis: results from the ReACCh-Out cohort

J Guzman , T Kerr , LM Ward , J Ma , K Oen , AM Rosenberg , BM Feldman , G Boire , K Houghton , P Dancey , R Scuccimarri , A Bruns , AM Huber , K Watanabe Duffy , NJ Shiff , RA Berard , DM Levy , E Stringer , K Morishita , N Johnson , DA Cabral , M Larché , RE Petty , RM Laxer , E Silverman , P Miettunen , AL Chetaille , E Haddad , L Spiegel , SE Turvey , H Schmeling , B Lang , J Ellsworth , SE Ramsey , J Roth , S Campillo , S Benseler , G Chédeville , R Schneider , SML Tse , R Bolaria , K Gross , D Feldman , B Cameron , R Jurencak , J Dorval , C LeBlanc , C St Cyr , M Gibbon , RSM Yeung , CM Duffy , LB Tucker

To read the full abstract: Pediatr Rheumatol Online J. 2017Aug 22;15(1):68This large prospective study analysed growth in children with JIA during a 3-year period from diagnosis. Interesting findings emerge: the heights and weights of these patients, clearly compromised in historical cohorts, appeared nearly normal. Increased risk of growth impairment was noted in patients with systemic arthr...

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ESPE Yearbook of Paediatric Endocrinology

11.2. Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signalling

9.8 Growth and weight gain in children with juvenile idiopathic arthritis: results from the ReACCh-Out cohort

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